Article
Polyunsaturated fatty acids interact with the PPARA-L162V polymorphism to affect plasma triglyceride and apolipoprotein C-III concentrations in the Framingham Heart Study.
The Journal of nutrition - 1 Mar 2005
Tai E Shyong, Corella Dolores, Demissie Serkalem, Cupples L Adrienne, Coltell Oscar, Schaefer Ernst J, Tucker Katherine L, Ordovas Jose M
Abstract excerpt
Peroxisome proliferator-activated receptor alpha (PPARalpha) is a nuclear transcription factor regulating multiple genes involved in lipid metabolism. It was shown that a common leucine to valine (L162V) substitution at the PPARalpha gene (PPARA) is functional and affects transactivation activity of PPARalpha ligands, such as PUFA, on a concentration-dependent basis. The current study examined this gene-nutrient...
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