Article
Testing candidate genes for non-syndromic oral clefts using a case-parent trio design.
Genetic epidemiology - 1 Jan 2002
Beaty Terri H, Hetmanski J B, Zeiger J S, Fan Y T, Liang K Y, VanderKolk C A, McIntosh I
Abstract excerpt
Markers in five candidate genes were examined on 269 case-parent trios ascertained through a child with an isolated, non-syndromic oral cleft (cleft lip, CL; cleft palate, CP; or cleft lip and palate, CLP). Cases and their parents were ascertained through treatment centers in Maryland. Markers at two of the five candidate genes, transforming growth factor beta3 (TGFbeta3) and MSX1, showed consistent evidence of...
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