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Article

Association of MSX1 and TGFB3 with nonsyndromic clefting in humans.

American journal of human genetics - 1 Aug 1998

Lidral A C, Romitti P A, Basart A M, Doetschman T, Leysens N J, Daack-Hirsch S, Semina E V, Johnson L R, Machida J, Burds A, Parnell T J, Rubenstein J L, Murray J C

Abstract excerpt

Nonsyndromic cleft lip with or without cleft palate (CL/P) and nonsyndromic cleft palate only (CPO) are common congenital anomalies with significant medical, psychological, social, and economic ramifications. Both CL/P and CPO are examples of complex genetic traits. There exists sufficient evidence to hypothesize that disease loci for CL/P and CPO can be identified by a candidate-gene linkage-disequilibrium (LD)...

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Source

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Identifiers

PMID: 9683588
DOI: 10.1086/301956
PMCID: PMC1377298

Genes

CPO
MSX1
TGFB3
BCL3
DLX2
TGFA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Association of MSX1 and TGFB3 with nonsyndromic clefting in humans.PMID 9683588Read ↗

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Evaluation of Two Putative Susceptibility Loci for Oral Clefts in the Danish PopulationSemantic proximity Read ↗

Variants of developmental genes (TGFA, TGFB3, and MSX1) and their associations with orofacial clefts: a case-parent triad analysis.Semantic proximity Read ↗

Transforming Growth Factor Alpha Taq I Polymorphisms and Nonsyndromic Cleft Lip and/or Palate Risk: A Meta-Analysis.Semantic proximity Read ↗

Association between TGFB3 and nonsyndromic cleft lip with or without cleft palate in a Chilean population.Semantic proximity Read ↗

Studies of the candidate genes TGFB2, MSX1, TGFA, and TGFB3 in the etiology of cleft lip and palate in the Philippines.Semantic proximity Read ↗

MSX1 and TGFB3 contribute to clefting in South America.Semantic proximity Read ↗

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Transforming growth factor alpha locus and nonsyndromic cleft lip with or without cleft palate: a reappraisal.Semantic proximity Read ↗

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