Article
Medical sequencing of candidate genes for nonsyndromic cleft lip and palate.
PLoS genetics - 1 Dec 2005
Vieira Alexandre R, Avila Joseph R, Daack-Hirsch Sandra, Dragan Ecaterina, Félix Têmis M, Rahimov Fedik, Harrington Jill, Schultz Rebecca R, Watanabe Yoriko, Johnson Marla, Fang Jennifer, O'Brien Sarah E, Orioli Iêda M, Castilla Eduardo E, Fitzpatrick David R, Jiang Rulang, Marazita Mary L, Murray Jeffrey C
Abstract excerpt
Nonsyndromic or isolated cleft lip with or without cleft palate (CL/P) occurs in wide geographic distribution with an average birth prevalence of 1/700. We used direct sequencing as an approach to study candidate genes for CL/P. We report here the results of sequencing on 20 candidate genes for clefts in 184 cases with CL/P selected with an emphasis on severity and positive family history. Genes were selected...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.