Article
Regulation of constitutive STAT5 phosphorylation in acute myeloid leukemia blasts.
Leukemia - 1 Dec 2001
Birkenkamp K U, Geugien M, Lemmink H H, Kruijer W, Vellenga E
Abstract excerpt
In the present study, we examined the underlying mechanism, which causes the constitutive tyrosine phosphorylation of signal transducer and activator of transcription 5 (STAT5) in acute myeloid leukemia (AML) blasts. Constitutive STAT5 phosphorylation was observed in 18 of 26 (69%) patients with AML. The constitutive STAT5 phosphorylation was caused by different mechanisms. In the majority of the investigated...
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