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Article

The Role of Signal Transducer and Activator of Transcription Factors in Leukemogenesis

13 Jan 2004

Abstract excerpt

Human leukemias are frequently associated with the aberrant expression of activated fusion tyrosine kinases or activated protein tyrosine kinases carrying insertional or point mutations. The activated kinase enzymes typically phosphorylate one or more signal transducer and activator of transcription (STAT) factors, which translocate to the cell nucleus and regulate the expression of genes associated with survival...

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Identifiers

PMID: 14722044
DOI: 10.1200/jco.2004.10.124

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