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Article

Phosphoproteomic analysis of AML cell lines identifies leukemic oncogenes.

Leukemia research - 1 Sept 2006

Walters Denise K, Goss Valerie L, Stoffregen Eric P, Gu Ting-Lei, Lee Kimberly, Nardone Julie, McGreevey Laura, Heinrich Michael C, Deininger Michael W, Polakiewicz Roberto, Druker Brian J

Abstract excerpt

STAT5 is constitutively phosphorylated in leukemic cells in approximately 70% of acute myeloid leukemia (AML) patients. To identify kinase candidates potentially responsible for STAT5 phosphorylation, we used liquid chromatography-tandem mass spectrometry (LC-MS/MS) mass spectrometry to detect phosphoproteins in AML cell lines. We established TEL-ARG and BCR-ABL fusion proteins as the mechanism underlying STAT5...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16464493
DOI: 10.1016/j.leukres.2006.01.001

Genes

JAK2
BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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