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Ulcerative colitis and Crohn's disease: molecular genetics and clinical implications

19 Nov 2001

Abstract excerpt

The genetics of inflammatory bowel disease (IBD) is an area of enormous topical interest. Crohn's disease is one of the first polygenic diseases in which a susceptibility gene ( NOD2 ) has been positionally cloned, providing proof of principle for methodologies that to date had been mired in uncertainty. IBD has been highly unusual among polygenic diseases in providing replicated candidate susceptibility regions...

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PMID: 14987369
DOI: 10.1017/s146239940100391x

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