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Article

Characterization of a human cytomegalovirus with phosphorylation site mutations in the immediate-early 2 protein.

Journal of virology - 1 Jan 2002

Heider Julie A, Yu Yongjun, Shenk Thomas, Alwine James C

Abstract excerpt

A human cytomegalovirus mutant (TNsubIE2P) was constructed with alanine substitutions of four residues (T27, S144, T233, and S234) previously shown to be phosphorylated in the immediate-early 2 (IE2) protein. This mutant grew as well as the wild type at both low and high multiplicities of infection. The mutant activated the major immediate-early, UL4, and UL44 promoters to similar levels, and with similar...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 11752183
DOI: 10.1128/jvi.76.2.928-932.2002
PMCID: PMC136832

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Source receipt: pubmed, retrieved 7 Sept 2026.

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