Article
Construction of a rationally designed human cytomegalovirus variant encoding a temperature-sensitive immediate-early 2 protein.
Proceedings of the National Academy of Sciences of the United States of America - 5 Mar 2002
Heider Julie A, Bresnahan Wade A, Shenk Thomas E
Abstract excerpt
We generated a set of cysteine-to-glycine mutations and screened them to identify a temperature-sensitive allele of the human cytomegalovirus UL122 gene, which encodes the immediate-early 2 transcriptional activating protein. The mutant allele contains a single base pair substitution at amino acid 510. In transcription activation assays, the mutant protein activated the simian virus 40 early and human...
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