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Article

Promoter-specific trans activation and repression by human cytomegalovirus immediate-early proteins involves common and unique protein domains.

Journal of virology - 1 Apr 1990

Stenberg R M, Fortney J, Barlow S W, Magrane B P, Nelson J A, Ghazal P

Abstract excerpt

trans activation of promoters by viral regulatory proteins provides a useful tool to study coordinate control of gene expression. Immediate-early (IE) regions 1 and 2 of human cytomegalovirus (CMV) code for a series of proteins that originate from differentially spliced mRNAs. These IE proteins are proposed to regulate the temporal expression of the viral genome. To examine the structure and function of the IE...

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Identifiers

PMID: 2157043
DOI: 10.1128/JVI.64.4.1556-1565.1990
PMCID: PMC249290

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