Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The effects of deleting the mouse neurotensin receptor NTR1 on central and peripheral responses to neurotensin.

The Journal of pharmacology and experimental therapeutics - 1 Jan 2002

Pettibone Douglas J, Hess J Fred, Hey Patricia J, Jacobson Marlene A, Leviten Michael, Lis Edward V, Mallorga Pierre J, Pascarella Danette M, Snyder Melissa A, Williams Jacinta B, Zeng Zhizhen

Abstract excerpt

Mice deficient in the neurotensin (NT)-1 receptor (NTR1) were developed to characterize the NT receptor subtypes that mediate various in vivo responses to NT. F2 generation (C57BL6/Sv129J) NTR1 knockout (-/-) mice were viable, and showed normal growth and overt behavior. The -/- mice lacked detectable NTR1 radioligand binding in brain, whereas NTR2 receptor binding density appeared normal compared with wild-type...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Analgesics
Share to Body Temperature

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gastrointestinal Motility

Share to Pain Measurement

Share to Peripheral Nervous System

Share to Postural Balance

Share to Psychomotor Performance

Share to Radioligand Assay

Source

Identifiers

PMID: 11752130
DOI: 10.1124/jpet.300.1.305

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The effects of deleting the mouse neurotensin receptor NTR1 on central and peripheral responses to neurotensin.PMID 11752130Read ↗

Identification and expression of a variant isoform of the levocabastine-sensitive neurotensin receptor in the mouse central nervous system.Semantic proximity Read ↗

Ablation of Tacr2 in mice leads to gastric emptying disturbance.Semantic proximity Read ↗

Neurotensin Receptor and Its mRNA Are Expressed in Many Human Colon Cancer Cell Lines But Not in Normal Colonic Epithelium: Binding Studies and RT-PCR ExperimentsSemantic proximity Read ↗

Structure of the agonist-bound neurotensin receptor.Semantic proximity Read ↗

Sensorimotor gating in NTS1 and NTS2 null mice: effects of d-amphetamine, dizocilpine, clozapine and NT69L.Semantic proximity Read ↗

Mice lacking cannabinoid CB1-, CB2-receptors or both receptors show increased susceptibility to trinitrobenzene sulfonic acid (TNBS)-induced colitis.Semantic proximity Read ↗

A peptide-neurotensin conjugate that crosses the blood-brain barrier induces pharmacological hypothermia associated with anticonvulsant, neuroprotective and anti-inflammatory properties following status epilepticus in miceSemantic proximity Read ↗

Signal transduction pathways mediating neurotensin-stimulated interleukin-8 expression in human colonocytes.Semantic proximity Read ↗

High-fat diet-induced obesity alters nitric oxide-mediated neuromuscular transmission and smooth muscle excitability in the mouse distal colon.Semantic proximity Read ↗

Opioid-related changes in nociceptive threshold and in tissue levels of enkephalins after target disruption of the gene for neutral endopeptidase (EC 3.4.24.11) in mice.Semantic proximity Read ↗

Common quantitative trait loci for alcohol-related behaviors and central nervous system neurotensin measures: hypnotic and hypothermic effects.Semantic proximity Read ↗

Expression of Neurotensin and NT1 Receptor in Human Breast Cancer: A Potential Role in Tumor ProgressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.