Article
Ablation of Tacr2 in mice leads to gastric emptying disturbance.
Neurogastroenterology and motility - 1 Nov 2017
Mao Y-L, Shen C-L, Zhou T, Ma B-T, Tang L-Y, Wu W-T, Zhang H-X, Lu H-L, Xu W-X, Wang Z-G
Abstract excerpt
BACKGROUND: Tacr2 is one of the G protein-coupled receptors(GPCRs) that mediate the biological actions of tachykinins. It is abundantly expressed in the gastrointestinal (GI) system and is thought to play an important role in GI motility, secretion, and visceral sensitivity. Previously, the physiological and pathophysiological functions of Tacr2 were mainly studied using Tacr2 selective agonists or antagonists....
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