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Article

Signal transduction pathways mediating neurotensin-stimulated interleukin-8 expression in human colonocytes.

The Journal of biological chemistry - 30 Nov 2001

Zhao D, Keates A C, Kuhnt-Moore S, Moyer M P, Kelly C P, Pothoulakis C

Abstract excerpt

Neurotensin (NT), a neuropeptide released in the gastrointestinal tract in response to several stimuli, is involved in the pathophysiology of colonic inflammation. However, the molecular mechanism(s) mediating this proinflammatory response remains unclear. We found that NCM460, non-transformed human colonocytes, express a functional high affinity NT receptor that mediates NT-induced Erk activation. By using...

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PMID: 11574537
DOI: 10.1074/jbc.M104942200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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