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Article

High-fat diet-induced obesity alters nitric oxide-mediated neuromuscular transmission and smooth muscle excitability in the mouse distal colon.

American journal of physiology. Gastrointestinal and liver physiology - 1 Aug 2016

Bhattarai Yogesh, Fried David, Gulbransen Brian, Kadrofske Mark, Fernandes Roxanne, Xu Hui, Galligan James

Abstract excerpt

We tested the hypothesis that colonic enteric neurotransmission and smooth muscle cell (SMC) function are altered in mice fed a high-fat diet (HFD). We used wild-type (WT) mice and mice lacking the β1-subunit of the BK channel (BKβ1 (-/-)). WT mice fed a HFD had increased myenteric plexus oxidative stress, a 28% decrease in nitrergic neurons, and a 20% decrease in basal nitric oxide (NO) levels. Circular muscle...

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Identifiers

PMID: 27288421
DOI: 10.1152/ajpgi.00085.2016
PMCID: PMC5007291

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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