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Article

Pro‐apoptotic effect of presenilin 2 (PS2) overexpression is associated with down‐regulation of Bcl‐2 in cultured neurons

15 Dec 2001

Abstract excerpt

Presenilin 2 (PS2) is a polytopic membrane protein that is mutated in some cases of familial Alzheimer's disease (AD). The normal functions of PS2 and its pathogenic role in AD remain unclear. We investigated the biological role of this protein in neurons, using adenovirus-mediated transduction of the PS2 gene into rat primary cortical neurons. Immunocytochemical analyses demonstrated increased PS2...

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PMID: 11752057
DOI: 10.1046/j.1471-4159.2001.00638.x

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Pro‐apoptotic effect of presenilin 2 (PS2) overexpression is associated with down‐regulation of Bcl‐2 in cultured neuronsPMID 11752057Read ↗

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