Monogenic determinants of familial Alzheimer's disease: presenilin-2 mutations.

doi:10.1007/s000180050220

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Article

Monogenic determinants of familial Alzheimer's disease: presenilin-2 mutations.

Cellular and molecular life sciences : CMLS - 1 Sept 1998

Renbaum P, Levy-Lahad E

Abstract excerpt

Presenilin-2 (PS2) is one of three genes [amyloid precursor protein (APP), presenilin-1 (PS1) and PS2] shown to cause familial Alzheimer's disease (FAD), and is highly homologous to PS1. Currently demonstrated functions of PS2 include interactions with APP and A beta, and participation in apoptot...

Topics

Adult
Age of Onset
Aged
Alzheimer Disease
Amyloid beta-Peptides
Animals
Apoptosis
Caenorhabditis elegans Proteins
Evolution, Molecular
Gene Expression
Gene Frequency
Helminth Proteins
Humans
Membrane Proteins
Middle Aged
Mutation
Phenotype
Presenilin-2

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