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Article

Monogenic determinants of familial Alzheimer's disease: presenilin-2 mutations.

Cellular and molecular life sciences : CMLS - 1 Sept 1998

Renbaum P, Levy-Lahad E

Abstract excerpt

Presenilin-2 (PS2) is one of three genes [amyloid precursor protein (APP), presenilin-1 (PS1) and PS2] shown to cause familial Alzheimer's disease (FAD), and is highly homologous to PS1. Currently demonstrated functions of PS2 include interactions with APP and A beta, and participation in apoptotic pathways. PS2 FAD mutations influence APP processing in a manner predicted to promote amyloid formation and also...

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Identifiers

PMID: 9791533
DOI: 10.1007/s000180050220
PMCID: PMC11147343

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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