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Article

Priming polyvalent immunity by DNA vaccines expressing chimeric antigens with a stress protein-capturing, viral J-domain.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jul 2002

Schirmbeck Reinhold, Kwissa Marcin, Fissolo Nicolas, Elkholy Shereen, Riedl Petra, Reimann Jörg

Abstract excerpt

The N-terminal domain of large tumor antigens (T-Ag) of polyomaviruses forms a DnaJ-like structure with a conserved J domain that associates with constitutively expressed stress protein heat shock protein (hsp)73. Mutant (but not wild-type) SV40 T-Ag show stable, ATP-dependent binding to the stress protein hsp73 when expressed in cells from different vertebrate tissues. Intracellular T/hsp73 complexes accumulate...

Read the complete abstract on PubMed

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Identifiers

PMID: 12039856
DOI: 10.1096/fj.01-0993fje

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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