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Article

The LIM Domain Protein LMO4 Interacts with the Cofactor CtIP and the Tumor Suppressor BRCA1 and Inhibits BRCA1 Activity

1 Mar 2002

Abstract excerpt

LMO4 belongs to the LIM-only (LMO) group of transcriptional regulators that appear to function as molecular adaptors for protein-protein interactions. Expression of the LMO4 gene is developmentally regulated in the mammary gland and is up-regulated in primary breast cancers. Using LMO4 in a yeast two-hybrid screen, we have identified the cofactor CtIP as an LMO4-binding protein. Interaction with CtIP appeared to...

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PMID: 11751867
DOI: 10.1074/jbc.m110603200

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The LIM Domain Protein LMO4 Interacts with the Cofactor CtIP and the Tumor Suppressor BRCA1 and Inhibits BRCA1 ActivityPMID 11751867Read ↗

The LIM domain gene <i>LMO4</i> inhibits differentiation of mammary epithelial cells <i>in vitro</i> and is overexpressed in breast cancerSemantic proximity Read ↗

Tandem LIM domains provide synergistic binding in the LMO4:Ldb1 complex.Semantic proximity Read ↗

Negative Regulation of Estrogen Receptor α Transactivation Functions by LIM Domain Only 4 ProteinSemantic proximity Read ↗

Mutational analysis of the LMO4 gene, encoding a BRCA1-interacting protein, in breast carcinomas.Semantic proximity Read ↗

LMO7 and LIMCH1 interact with LRIG proteins in lung cancer, with prognostic implications for early-stage diseaseSemantic proximity Read ↗

Loss of the LIM domain protein Lmo4 in the mammary gland during pregnancy impedes lobuloalveolar development.Semantic proximity Read ↗

Aberrant expression of LMO4 induces centrosome amplification and mitotic spindle abnormalities in breast cancer cells.Semantic proximity Read ↗

A DNA-binding mutant of TAL1 cooperates with LMO2 to cause T cell leukemia in mice.Semantic proximity Read ↗

LMO2 Oncoprotein Stability in T-Cell Leukemia Requires Direct LDB1 Binding.Semantic proximity Read ↗

Identification of LMO2 transcriptome and interactome in diffuse large B-cell lymphomaSemantic proximity Read ↗

LIM-Only Protein 4 (LMO4) and LIM Domain Binding Protein 1 (LDB1) Promote Growth and Metastasis of Human Head and Neck Cancer (LMO4 and LDB1 in Head and Neck Cancer)Semantic proximity Read ↗

Mouse Deformed epidermal autoregulatory factor 1 recruits a LIM domain factor, LMO-4, and CLIM coregulatorsSemantic proximity Read ↗

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