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Negative Regulation of Estrogen Receptor α Transactivation Functions by LIM Domain Only 4 Protein

15 Nov 2005

Abstract excerpt

LIM domain only 4 (LMO4), a member of the LIM-only family of transcriptional coregulatory proteins, consists of two LIM protein-protein interaction domains that enable it to function as a linker protein in multiprotein complexes. Here, we have identified estrogen receptor alpha (ERalpha) and its corepressor, metastasis tumor antigen 1 (MTA1), as two novel binding partners of LMO4. Interestingly, LMO4 exhibited...

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PMID: 16288053
DOI: 10.1158/0008-5472.can-05-2268

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Negative Regulation of Estrogen Receptor α Transactivation Functions by LIM Domain Only 4 ProteinPMID 16288053Read ↗

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