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Article

Mutational analysis of the LMO4 gene, encoding a BRCA1-interacting protein, in breast carcinomas.

International journal of cancer - 20 Oct 2003

Sutherland Kate D, Visvader Jane E, Choong David Y H, Sum Eleanor Y M, Lindeman Geoffrey J, Campbell Ian G

Abstract excerpt

The LIM domain-only genes LMO1 and LMO2 are translocated in acute T cell leukemia (T-ALL) and have been shown to be oncogenes in T lymphoid cells. LMO4, the fourth member of this family, is overexpressed in more than 50% of sporadic breast cancers, suggesting a role in breast oncogenesis. We rece...

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Topics

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Share to Adaptor Proteins, Signal Transducing
Share to BRCA1 Protein
Share to DNA, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single-Stranded Conformational

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Source

Identifiers

PMID: 12925972
DOI: 10.1002/ijc.11343

Genes

LMO4
BRCA1
LMO1
LMO2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12925972-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutational analysis of the LMO4 gene, encoding a BRCA1-interacting protein, in breast carcinomas.PMID 12925972Read ↗

The LIM Domain Protein LMO4 Interacts with the Cofactor CtIP and the Tumor Suppressor BRCA1 and Inhibits BRCA1 ActivitySemantic proximity Read ↗

The LIM domain gene <i>LMO4</i> inhibits differentiation of mammary epithelial cells <i>in vitro</i> and is overexpressed in breast cancerSemantic proximity Read ↗

Activation of the LMO2 oncogene through a somatically acquired neomorphic promoter in T-cell acute lymphoblastic leukemia.Semantic proximity Read ↗

Aberrant expression of LMO4 induces centrosome amplification and mitotic spindle abnormalities in breast cancer cells.Semantic proximity Read ↗

A DNA-binding mutant of TAL1 cooperates with LMO2 to cause T cell leukemia in mice.Semantic proximity Read ↗

LMO2 Oncoprotein Stability in T-Cell Leukemia Requires Direct LDB1 Binding.Semantic proximity Read ↗

Conformational flexibility of the oncogenic protein LMO2 primes the formation of the multi-protein transcription complex.Semantic proximity Read ↗

Tandem LIM domains provide synergistic binding in the LMO4:Ldb1 complex.Semantic proximity Read ↗

A previously unrecognized promoter of LMO2 forms part of a transcriptional regulatory circuit mediating LMO2 expression in a subset of T-acute lymphoblastic leukaemia patientsSemantic proximity Read ↗

NME1 protein expression and loss of heterozygosity mutations in primary human breast tumors.Semantic proximity Read ↗

Negative Regulation of Estrogen Receptor α Transactivation Functions by LIM Domain Only 4 ProteinSemantic proximity Read ↗

TheLMO2T-Cell Oncogene Is Activated via Chromosomal Translocations or Retroviral Insertion during Gene Therapy but Has No Mandatory Role in Normal T-Cell DevelopmentSemantic proximity Read ↗

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