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Article

Aberrant expression of LMO4 induces centrosome amplification and mitotic spindle abnormalities in breast cancer cells.

The Journal of pathology - 1 Nov 2010

Montañez-Wiscovich Marjorie E, Shelton Melissa D, Seachrist Darcie D, Lozada Kristen L, Johnson Emhonta, Miedler John D, Abdul-Karim Fadi W, Visvader Jane E, Keri Ruth A

Abstract excerpt

The LIM-only protein, LMO4, is a transcriptional modulator overexpressed in breast cancer. It is oncogenic in murine mammary epithelium and is required for G2/M progression of ErbB2-dependent cells as well as growth and invasion of other breast cancer cell types. However, the mechanisms underlying the oncogenic activity of LMO4 remain unclear. Herein, we show that LMO4 is expressed in all breast cancer subtypes...

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Topics

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Share to Cell Cycle
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, BRCA1

Share to LIM Domain Proteins

Share to Mitotic Index

Share to Receptors, Estrogen

Share to RNA, Neoplasm

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Source

Open in PubMed Open full text

Identifiers

PMID: 20814902
DOI: 10.1002/path.2762
PMCID: PMC3600378

Genes

LMO4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

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Aberrant expression of LMO4 induces centrosome amplification and mitotic spindle abnormalities in breast cancer cells.PMID 20814902Read ↗

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The LIM Domain Protein LMO4 Interacts with the Cofactor CtIP and the Tumor Suppressor BRCA1 and Inhibits BRCA1 ActivitySemantic proximity Read ↗

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