Article
Activation of the ATPase activity of hsp90 by the stress-regulated cochaperone aha1.
Molecular cell - 1 Dec 2002
Panaretou Barry, Siligardi Giuliano, Meyer Philippe, Maloney Alison, Sullivan Janis K, Singh Shradha, Millson Stefan H, Clarke Paul A, Naaby-Hansen Soren, Stein Rob, Cramer Rainer, Mollapour Mehdi, Workman Paul, Piper Peter W, Pearl Laurence H, Prodromou Chrisostomos
Abstract excerpt
Client protein activation by Hsp90 involves a plethora of cochaperones whose roles are poorly defined. A ubiquitous family of stress-regulated proteins have been identified (Aha1, activator of Hsp90 ATPase) that bind directly to Hsp90 and are required for the in vivo Hsp90-dependent activation of clients such as v-Src, implicating them as cochaperones of the Hsp90 system. In vitro, Aha1 and its shorter homolog,...
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