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Article

Linkage analysis of susceptibility to hyperoxia. Nrf2 is a candidate gene.

American journal of respiratory cell and molecular biology - 1 Jan 2002

Cho Hye-Youn, Jedlicka Anne E, Reddy Sekhar P M, Zhang Liu-Yi, Kensler Thomas W, Kleeberger Steven R

Abstract excerpt

A strong role for reactive oxygen species (ROS) has been proposed in the pathogenesis of a number of lung diseases. Hyperoxia (> 95% oxygen) generates ROS and extensive lung damage, and has been used as a model of oxidant injury. However, the precise mechanisms of hyperoxia-induced toxicity have not been completely clarified. This study was designed to identify hyperoxia susceptibility genes in C57BL/6J...

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Identifiers

PMID: 11751202
DOI: 10.1165/ajrcmb.26.1.4536

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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