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Article

Genetic susceptibility to ozone-induced lung hyperpermeability: role of toll-like receptor 4.

American journal of respiratory cell and molecular biology - 1 May 2000

Kleeberger S R, Reddy S, Zhang L Y, Jedlicka A E

Abstract excerpt

The pollutant ozone (O(3)) induces lung hyperpermeability and inflammation in humans and animal models. Among inbred strains of mice, there is a 3-fold difference in total protein (a marker of permeability) recovered in bronchoalveolar lavage (BAL) fluid after a 72-h exposure to 0.3 ppm O(3). To determine the chromosomal locations of susceptibility genes, we performed a genome screen using recombinant inbred (RI)...

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Source

Identifiers

PMID: 10783135
DOI: 10.1165/ajrcmb.22.5.3912

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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