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Article

Association of Nrf2 polymorphism haplotypes with acute lung injury phenotypes in inbred strains of mice.

Antioxidants & redox signaling - 1 Feb 2015

Cho Hye-Youn, Jedlicka Anne E, Gladwell Wesley, Marzec Jacqui, McCaw Zackary R, Bienstock Rachelle J, Kleeberger Steven R

Abstract excerpt

AIMS: Nrf2 is a master transcription factor for antioxidant response element (ARE)-mediated cytoprotective gene induction. A protective role for pulmonary Nrf2 was determined in model oxidative disorders, including hyperoxia-induced acute lung injury (ALI). To obtain additional insights into the function and genetic regulation of Nrf2, we assessed functional single nucleotide polymorphisms (SNPs) of Nrf2 in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mice, Inbred Strains

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Share to NF-E2-Related Factor 2

Share to Promoter Regions, Genetic

Share to Protein Structure, Secondary

Source

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Identifiers

PMID: 25268541
DOI: 10.1089/ars.2014.5942
PMCID: PMC4298158

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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