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Article

Functional polymorphisms in the transcription factor NRF2 in humans increase the risk of acute lung injury.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jul 2007

Marzec Jacqui M, Christie Jason D, Reddy Sekhar P, Jedlicka Anne E, Vuong Hue, Lanken Paul N, Aplenc Richard, Yamamoto Tae, Yamamoto Masayuki, Cho Hye-Youn, Kleeberger Steven R

Abstract excerpt

We recently used positional cloning to identify the transcription factor Nrf2 (NF-E2 related factor 2) as a susceptibility gene in a murine model of oxidant-induced acute lung injury (ALI). NRF2 binds to antioxidant response elements (ARE) and up-regulates protective detoxifying enzymes in response to oxidative stress. This led us to investigate NRF2 as a candidate susceptibility gene for risk of development of...

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PMID: 17384144
DOI: 10.1096/fj.06-7759com

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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