Article
Association of polymorphisms of the transforming growth factor-beta1 gene with the rate of progression of HCV-induced liver fibrosis.
Clinica chimica acta; international journal of clinical chemistry - 1 Feb 2002
Gewaltig Jan, Mangasser-Stephan Kerstin, Gartung Carsten, Biesterfeld Stefan, Gressner Axel M
Abstract excerpt
BACKGROUND: The objective of the present study was to elucidate possible relationships between four polymorphisms of the TGF-beta1 gene (-800G>A; -509C>T; Leu10Pro; Arg25Pro) and stage, histological activity grade and progression rate of liver fibrosis, classified according to the METAVIR-score. METHODS: Three study groups, i.e. 48 patients with hepatic fibrosis (26 with known duration of hepatitis C virus...
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