Article
Evaluation of the transforming growth factor beta1 codon 25 (Arg-->Pro) polymorphism in alcoholic liver disease.
Cytokine - 1 Apr 2008
Osterreicher Christoph H, Halangk Juliane, Berg Thomas, Patsenker Eleonora, Homann Nils, Hellerbrand Claus, Seitz Helmut K, Eurich Dennis, Stickel Felix
Abstract excerpt
INTRODUCTION: Liver cirrhosis develops only in a minority of heavy drinkers. Genetic factors may account for some variation in the progression of fibrosis in alcoholic liver disease (ALD). Transforming growth factor beta 1 (TGFbeta1) is a key profibrogenic cytokine in fibrosis and its gene contai...
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