Article
Transforming growth factor-beta-1 genetic polymorphism in Japanese patients with chronic hepatitis C virus infection.
Journal of gastroenterology and hepatology - 1 Oct 2003
Suzuki Seiji, Tanaka Yasuhito, Orito Etsuro, Sugauchi Fuminaka, Hasegawa Izumi, Sakurai Mayumi, Fujiwara Kei, Ohno Tomoyoshi, Ueda Ryuzo, Mizokami Masashi
Abstract excerpt
BACKGROUND AND AIM: Transforming growth factor beta-1 (TGF-beta1) is one of the most dominant fibrogenic cytokines in hepatic fibrosis. The aim of the present study was to examine the effects of TGF-beta1 polymorphisms in Japanese patients with chronic hepatitis C virus (HCV) infection and in healthy control subjects. METHODS: The TGF-beta1 genotypes at codon 10 and codon 25 were determined in 206 Japanese...
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