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Article

Lack of genotoxicity of bitumen fumes in transgenic mouse lung.

Toxicology - 15 Jan 2002

Micillino Jean Claude, Coulais Catherine, Binet Stéphane, Bottin Marie Claire, Keith Gérard, Moulin David, Rihn Bertrand Henri

Abstract excerpt

During hot application of bitumen containing materials, e.g. in hot paving or roofing, fumes are emitted that contain polycyclic aromatic compounds. Previous studies with rodents exposed to bitumen and coal-tar fume condensates showed formation of DNA adducts. In order to clarify the genotoxicity of bitumen fumes, we designed a study by using mice carrying a reporter gene for mutagenesis analysis and exposed by...

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PMID: 11750079
DOI: 10.1016/s0300-483x(01)00507-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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