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Article

A novel human tumor necrosis factor alpha mutant showed potent antitumor activity and reduced toxicity in vivo.

Acta pharmacologica Sinica - 1 Jul 2001

Lu F, Chen Z M, Liu Q H, Chen C Q

Abstract excerpt

AIM: To study the antitumor activity and systemic toxicity of human tumor necrosis factor alpha (hTNFalpha) mutant M2 (R2K-N30S-R32W-L157F-hTNFalpha). METHODS: Mouse sarcoma S180 tumors and hepatoma HAC tumors were implanted into mice, and human urocyst carcinoma CP-3 tumors were implanted into nude mice. The xenografted mice were injected with wild-type hTNFalpha and its mutant M2 at different doses. After 7 d...

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PMID: 11749826

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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