Article
Antitumor effect and mechanism of action of a tumor-targeting recombinant human tumor necrosis factor-α fusion protein mediated by urokinase.
Molecular medicine reports - 1 Jun 2015
Dai You-Chao, Yang Si-Min, Wang Xin, Zhou Yong-Jun, Hou Gan, Huang Di-Nan
Abstract excerpt
The aim of this study was to investigate the effect of the tumor‑targeting recombinant human tumor necrosis factor (rhTNF)‑α fusion protein mediated by urokinase on Sl80 tumor‑bearing mice, as well as to explore its mechanisms of action. Furthermore, the study aimed to observe the effect of the protein on liver and kidney function. rhTNF‑α fusion protein prokaryotic expression vectors were constructed using...
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