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Article

Ketamine blockade of voltage-gated sodium channels: evidence for a shared receptor site with local anesthetics.

Anesthesiology - 1 Dec 2001

Wagner L E, Gingrich K J, Kulli J C, Yang J

Abstract excerpt

BACKGROUND: The general anesthetic ketamine is known to be an N-methyl-D-aspartate receptor blocker. Although ketamine also blocks voltage-gated sodium channels in a local anesthetic-like fashion, little information exists on the molecular pharmacology of this interaction. We measured the effects of ketamine on sodium channels. METHODS: Wild-type and mutant (F1579A) recombinant rat skeletal muscle sodium channels...

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Identifiers

PMID: 11748399
DOI: 10.1097/00000542-200112000-00020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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