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Article

Cocaine binds to a common site on open and inactivated human heart (Na(v)1.5) sodium channels.

The Journal of physiology - 15 Jun 2002

O'Leary M E, Chahine M

Abstract excerpt

The inhibition by cocaine of the human heart Na+ channel (Na(v)1.5) heterologously expressed in Xenopus oocytes was investigated. Cocaine produced little tonic block of the resting channels but induced a characteristic, use-dependent inhibition during rapid, repetitive stimulation, suggesting that the drug preferentially binds to the open or inactivated states of the channel. To investigate further the state...

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Identifiers

PMID: 12068034
DOI: 10.1113/jphysiol.2001.016139
PMCID: PMC2290378

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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