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Article

A mutation in the local anaesthetic binding site abolishes toluene effects in sodium channels.

European journal of pharmacology - 28 Dec 2005

Gauthereau Marcia Y, Salinas-Stefanon Eduardo M, Cruz Silvia L

Abstract excerpt

Toluene is a solvent of abuse that inhibits cardiac sodium channels in a manner that resembles the action of local anaesthetics. The purpose of this work was to analyze toluene effects on skeletal muscle sodium channels with and without beta1 subunit (Nav1.4+beta1 and Nav1.4-beta1, respectively) expressed in Xenopus laevis oocytes and to compare them with those produced in the F1579A mutant channel lacking a...

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Identifiers

PMID: 16316648
DOI: 10.1016/j.ejphar.2005.10.069

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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