Article
Role of Src kinase in diperoxovanadate-mediated activation of phospholipase D in endothelial cells.
Archives of biochemistry and biophysics - 15 Dec 2001
Parinandi N L, Roy S, Shi S, Cummings R J, Morris A J, Garcia J G, Natarajan V
Abstract excerpt
We have shown earlier that oxidant-induced activation of phospholipase D (PLD) in vascular endothelial cells (ECs) is regulated by protein tyrosine kinases. To further understand the regulation of oxidant-induced PLD activation, we investigated the role of Src kinase. Treatment of bovine pulmonary artery ECs (BPAECs) with a model oxidant, diperoxovanadate (DPV), at 5 microM concentration, for 30 min, stimulated...
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