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Article

Role of p38 MAP kinase in diperoxovanadate-induced phospholipase D activation in endothelial cells.

American journal of physiology. Lung cellular and molecular physiology - 1 Aug 2001

Natarajan V, Scribner W M, Morris A J, Roy S, Vepa S, Yang J, Wadgaonkar R, Reddy S P, Garcia J G, Parinandi N L

Abstract excerpt

We previously demonstrated that diperoxovanadate (DPV), a synthetic peroxovanadium compound and cell-permeable oxidant that acts as a protein tyrosine phosphatase inhibitor and insulinomimetic, increased phospholipase D (PLD) activation in endothelial cells (ECs). In this report, the regulation of DPV-induced PLD activation by mitogen-activated protein kinases (MAPKs) was investigated. DPV activated extracellular...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11435219
DOI: 10.1152/ajplung.2001.281.2.L435

Genes

PLD1
PLD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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