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Article

Protein kinase D (PKD) activation in intact cells through a protein kinase C-dependent signal transduction pathway.

The EMBO journal - 15 Nov 1996

Zugaza J L, Sinnett-Smith J, Van Lint J, Rozengurt E

Abstract excerpt

Protein kinase D (PKD) is a serine/threonine protein kinase that is directly stimulated in vitro by phorbol esters and diacylglycerol in the presence of phospholipids. Here, we examine the regulation of PKD in living cells. Our results demonstrate that tumour-promoting phorbol esters, membrane-pe...

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Identifiers

PMID: 8947045
PMCID: PMC452445

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-8947045-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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Protein kinase D (PKD) activation in intact cells through a protein kinase C-dependent signal transduction pathway.PMID 8947045Read ↗

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Protein kinase D is a downstream target of protein kinase Ctheta.Semantic proximity Read ↗

Mechanisms of regulation of phospholipase D1 by protein kinase Calpha.Semantic proximity Read ↗

Selective binding of phorbol esters and diacylglycerol by individual C1 domains of the PKD family.Semantic proximity Read ↗

Involvement of phospholipase D2 in lysophosphatidate-induced transactivation of platelet-derived growth factor receptor-beta in human bronchial epithelial cells.Semantic proximity Read ↗

The phosphoinositide-dependent kinase, PDK-1, phosphorylates conventional protein kinase C isozymes by a mechanism that is independent of phosphoinositide 3-kinase.Semantic proximity Read ↗

Dual phospholipase C/diacylglycerol requirement for protein kinase D1 activation in lymphocytes.Semantic proximity Read ↗

Requirement of Syk-phospholipase C-gamma2 pathway for phorbol ester-induced phospholipase D activation in DT40 cells.Semantic proximity Read ↗

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