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Article

Alterations in Striatal Synaptic Transmission are Consistent across Genetic Mouse Models of Huntington’s Disease

1 May 2010

Abstract excerpt

Since the identification of the gene responsible for HD (Huntington's disease), many genetic mouse models have been generated. Each employs a unique approach for delivery of the mutated gene and has a different CAG repeat length and background strain. The resultant diversity in the genetic context and phenotypes of these models has led to extensive debate regarding the relevance of each model to the human...

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PMID: 20585470
DOI: 10.1042/an20100007

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