Article
Microarray analysis of the differential transformation mediated by Kirsten and Harvey Ras oncogenes in a human colorectal adenocarcinoma cell line.
International journal of cancer - 1 Feb 2006
Roberts Michael L, Drosopoulos Konstantinos G, Vasileiou Ioannis, Stricker Mona, Taoufik Era, Maercker Christian, Guialis Apostolia, Alexis Michael N, Pintzas Alexander
Abstract excerpt
Colorectal cancer arises after a series of mutational events in the colon epithelia and is often used as a model of the multistep progression of tumorigenesis. Mutations in Ki-Ras have been detected in some 50% of cases and are thought to occur at an early stage. Almost never do mutations arise in the loci of other Ras isoforms (Ha- and N-), leading to the assumption that Ki-Ras plays a unique role in...
Topics
- Adenocarcinoma
- Animals
- Cell Transformation, Neoplastic
- Colorectal Neoplasms
- DNA, Neoplasm
- Gene Expression Profiling
- Genes, ras
- Humans
- Mesoderm
- Mice
- Mice, SCID
- Mutation
- Oligonucleotide Array Sequence Analysis