Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Immature dendritic cells kill ovarian carcinoma cells by a FAS/FASL pathway, enabling them to sensitize tumor-specific CTLs.

International journal of cancer - 1 Nov 2001

Yang R, Xu D, Zhang A, Gruber A

Abstract excerpt

Dendritic cells (DCs) can acquire antigen(s) from apoptotic tumor cells, resulting in an immunogen that can induce class I-restricted cytotoxic T lymphocytes (CTLs) and protective tumor rejection. Here, we investigated whether DCs derived from ascitic monocytes of patients with ovarian carcinoma could kill autologous ovarian tumor cells and if as a result they would acquire antigen(s) enabling them to induce a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ascites
Share to CD8-Positive T-Lymphocytes
Share to Coculture Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dendritic Cells

Share to Fas Ligand Protein

Share to Jurkat Cells

Share to Monocytes

Share to T-Lymphocytes, Cytotoxic

Source

Identifiers

PMID: 11745422
DOI: 10.1002/ijc.1484

Genes

FAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Immature dendritic cells kill ovarian carcinoma cells by a FAS/FASL pathway, enabling them to sensitize tumor-specific CTLs.PMID 11745422Read ↗

TRANCE- and CD40 ligand-matured dendritic cells reveal MHC class I-restricted T cells specific for autologous tumor in late-stage ovarian cancer patients.Semantic proximity Read ↗

Activated apoptotic cells induce dendritic cell maturation via engagement of Toll-like receptor 4 (TLR4), dendritic cell-specific intercellular adhesion molecule 3 (ICAM-3)-grabbing nonintegrin (DC-SIGN), and β2 integrins.Semantic proximity Read ↗

Tumoricidal activity of human dendritic cells.Semantic proximity Read ↗

Ovarian cancer progression is controlled by phenotypic changes in dendritic cells.Semantic proximity Read ↗

Influence of ovarian cancer type I and type II microenvironment on the phenotype and function of monocyte-derived dendritic cells.Semantic proximity Read ↗

Delivery of alloantigens via apoptotic cells generates dendritic cells with an immature tolerogenic phenotype.Semantic proximity Read ↗

Tumor-associated human dendritic cell subsets: Phenotype, functional orientation, and clinical relevance.Semantic proximity Read ↗

Apoptotic, necrotic, or fused tumor cells: an equivalent source of antigen for dendritic cell loading.Semantic proximity Read ↗

Consequences of cell death: exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells.Semantic proximity Read ↗

Induction of leukemic-cell-specific cytotoxic T lymphocytes by autologous monocyte-derived dendritic cells presenting leukemic cell antigens.Semantic proximity Read ↗

Efficient migration of dendritic cells toward lymph node chemokines and induction of T(H)1 responses require maturation stimulus and apoptotic cell interaction.Semantic proximity Read ↗

Spontaneous apoptosis of blood dendritic cells in patients with breast cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.