Article
TRANCE- and CD40 ligand-matured dendritic cells reveal MHC class I-restricted T cells specific for autologous tumor in late-stage ovarian cancer patients.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Apr 2003
Schlienger Katia, Chu Christina S, Woo Edward Y, Rivers Patricia M, Toll Alanna J, Hudson Brian, Maus Marcela V, Riley James L, Choi Yongwon, Coukos George, Kaiser Larry R, Rubin Stephen C, Levine Bruce L, Carroll Richard G, June Carl H
Abstract excerpt
PURPOSE: The use of mature dendritic cells (DCs) presenting tumor-associated antigens (TAAs) to trigger tumor-specific T cells in vivo or in vitro represents a promising approach for cancer immunotherapy. We hypothesized that tumor antigens, mostly unidentified, are present on ovarian tumor cells and that mature DCs could be used to generate tumor-specific responses in unprimed patients. We also sought to measure...
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