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Structure and expression of the human immunoglobulin lambda genes.

1 Aug 1990

Abstract excerpt

We determined the DNA sequence of two large regions of chromosome 22: 33.7 kb containing the C lambda complex; and 5.2 kb 5' of the functionally rearranged lambda gene from the human myeloma, U266. Analysis of these sequences reveals the complete structure of the human C lambda complex and a previously undescribed seventh C lambda region that may encode the Ke+Oz- lambda protein. The seven constant regions are...

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PMID: 2115572
DOI: 10.1084/jem.172.2.609

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