Article
Differential susceptibity of transgenic mice lacking one or both apolipoprotein alleles to folate and vitamin E deprivation.
Journal of Alzheimer's disease : JAD - 1 Jun 2004
Shea Thomas B, Ortiz Daniela, Rogers Eugene
Abstract excerpt
The E4 allele of apolipoprotein E (ApoE) is associated with neurodegeneration in part due to increased oxidative stress. Transgenic mice lacking ApoE (-/-) represent a model for the consequences of deficiencies in ApoE function. Dietary deficiency in folate and vitamin E has previously been shown...
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