Article
Disruption of mesodermal enhancers for Igf2 in the minute mutant.
Development (Cambridge, England) - 1 Apr 2002
Davies Karen, Bowden Lucy, Smith Paul, Dean Wendy, Hill David, Furuumi Hiroyasu, Sasaki Hiroyuki, Cattanach Bruce, Reik Wolf
Abstract excerpt
The radiation-induced mutation minute (Mnt) in the mouse leads to intrauterine growth retardation with paternal transmission and has been linked to the distal chromosome 7 cluster of imprinted genes. We show that the mutation is an inversion, whose breakpoint distal to H19 disrupts and thus identifies an enhancer for Igf2 expression in skeletal muscle and tongue, and separates the gene from other mesodermal and...
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