Article
Variant eotaxin: its effects on the asthma phenotype.
The Journal of allergy and clinical immunology - 1 Dec 2001
Nakamura H, Luster A D, Nakamura T, In K H, Sonna L A, Deykin A, Israel E, Drazen J M, Lilly C M
Abstract excerpt
BACKGROUND: Eotaxin, a CC chemokine expressed in the asthmatic lung, has been associated with impaired lung function. The role of its variant form is unknown. OBJECTIVE: The purpose of this study was to detect the population frequency and effects of a known single-nucleotide polymorphism in the eotaxin gene in which a threonine residue (THR(23)) is substituted for the wild-type alanine (ALA(23)) at the 23rd amino...
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