Article
Association of Eotaxin gene family with asthma and serum total IgE.
Human molecular genetics - 1 Jun 2003
Shin Hyoung Doo, Kim Lyoung Hyo, Park Byung Lae, Jung Ji Hyun, Kim Jun Yeon, Chung Il-Yup, Kim Jung Sun, Lee June Hyuk, Chung Sun Hee, Kim Yong Hoon, Park Hae-Sim, Choi Jeong Hee, Lee Young Mok, Park Sung Woo, Choi Byoung Whui, Hong Soo-Jong, Park Choon-Sik
Abstract excerpt
The Eotaxin gene family (Eotaxin1, Eotaxin2 and Eotaxin3) recruits and activates CCR3-bearing cells such as eosinophils, mast cells and Th2 lymphocytes that play a major role in allergic disorders. To date, the effect of polymorphisms of Eotaxin genes on asthma phenotypes has not been thoroughly examined. In our research, we sequenced whole regions of the Eotaxin gene family to identify polymorphisms, which may...
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