Article
Inhibition of wild-type and mutant neuronal nicotinic acetylcholine receptors by local anesthetics.
Molecular pharmacology - 1 Dec 2001
Papke R L, Horenstein B A, Placzek A N
Abstract excerpt
Inhibition of neuronal nicotinic receptors can be regulated by the presence of specific amino acids in the beta subunit second transmembrane domain (TM2) domain. We show that the incorporation of a mutant beta4 subunit, which contains sequence from the muscle beta subunit at the TM2 6' and 10' positions of the neuronal beta4 subunit, greatly reduces the sensitivity of receptors to the local anesthetic...
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