Article
ARF function does not require p53 stabilization or Mdm2 relocalization.
Molecular and cellular biology - 1 Jan 2002
Korgaonkar Chandrashekhar, Zhao Lili, Modestou Modestos, Quelle Dawn E
Abstract excerpt
It is generally accepted that the ARF tumor suppressor induces p53-dependent growth arrest by sequestering the p53 antagonist Mdm2 in the nucleolus. Previous mutagenic studies of murine ARF suggested that residues 1 through 14 and 26 through 37 were critical for Mdm2 binding, while the latter domain also governed ARF nucleolar localization. We show that mouse ARF residues 6 to 10 and 21 to 25 are required for...
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